With brand name GLP-1 medications costing $900-$1,300 per month without insurance, compounded semaglutide and tirzepatide have become extremely popular. But how safe are they? Here is what the FDA, clinical studies, and regulatory agencies have to say. What Is Compounded Semaglutide? Compounded semaglutide is not FDA-approved. It is produced by licensed compounding pharmacies using semaglutide … Read more
All medications have side effects, and GLP-1 receptor agonists are no exception. But what does the actual clinical trial data say about how common, how severe, and how manageable these side effects are? Most Common Side Effects Across all major GLP-1 trials, gastrointestinal side effects are the most common. Here is the data from the … Read more
The SELECT trial is one of the most important studies in obesity medicine. Published in the New England Journal of Medicine in November 2023 (Lincoff et al., NEJM 2023;389:2221-2232), this landmark trial showed that semaglutide 2.4 mg (Wegovy) reduces cardiovascular risk in people with obesity — even if they do not have diabetes. What the … Read more
If you are considering a GLP-1 medication for weight loss, the most important question is: how much weight will I actually lose? Here is what the clinical trial data says at 3 months, 6 months, and 12+ months. Wegovy (Semaglutide 2.4 mg) — STEP Program Results The STEP clinical trial program included four phase 3 … Read more
Four GLP-1 drugs dominate the weight loss market in 2026: Wegovy (semaglutide), Zepbound (tirzepatide), Mounjaro (tirzepatide, approved for diabetes), and Ozempic (semaglutide, approved for diabetes but used off-label for weight loss). Here is what the clinical trials actually show. How They Work Semaglutide (Ozempic/Wegovy) is a GLP-1 receptor agonist. It mimics the GLP-1 hormone that … Read more
If you are looking for GLP-1 weight loss medications like Ozempic, Wegovy, or Mounjaro, telehealth providers are often the fastest and most affordable way to get them. In 2026, there are more options than ever. Here is how the top providers compare. Ro (Roman) Ro is one of the largest telehealth platforms in the US. … Read more